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While phase I and phase II enzymes are majorly responsible for chemically modifying the hydrophobic toxin to make it more hydrophilic, phase III is mostly related to the function of drug efflux performed by those drug transporters, such as the multidrug resistance (MDR) pump

These include a Creapure (Alzchem) creatine monohydrate combined with AstraGin (NuLiv Science) to support muscle recovery and reduce fatigue, BioCore Optimum Complete Digestive Enzymes Blend (ADM/Deerland Probiotics & Enzymes) to aid in digestion and nutrient absorption, and a vitamin C and glutathione combination formula featuring PureWay-C (One Innovation Labs) and Setria (Kyowa Hakko) for immune support, detoxification and cellular defense

It is probably broken down before it can reach CNS GIP receptors

10.14218/JERP.2019.00011 6

Kwon et al., 2009